* INCLUSION CRITERIA:
In order to be eligible to participate in this study, an individual must meet all of the following criteria:
* Adults 18-60 years of age with probable or definite EULAR-ACR criteria for adult or juvenile dermatomyositis (DM, JDM).
* Willingness to adhere to the general healthy diet pattern regimen, undergo dietary coaching on weekly to biweekly basis (10 sessions), and to complete online random reporting of dietary intake over a 6-month period.
* Ability and willingness to comply with taking 4 study pills twice a day for 6 months.
* Ability and willingness to wear ActiGraph device at home for 7 continuous days, twice in the study.
* Willingness and ability to complete and consent to study testing, including blood, stool, and urine samples, and imaging studies.
* Ability and willingness to complete a total of 5 study visits (screening, weeks -6, 0, 12, 24) onsite at NIH Clinical Center in Bethesda, Maryland.
* Has the ability/transportation methods to attend on-site visits. Willing to pay for travel and out-of-pocket expenses.
* Own or have reliable access to a computer, laptop or smart phone device (iPhone or Android) with internet access, and an active email address, to complete study consent form, online questionnaires, telehealth visits, and review online dietary education materials and videos.
* Ambulatory
* Must live within the United States.
* Must be proficient in the English language and complete questionnaires in English (forms validated in English). Ability and willingness to complete forms online.
* Moderately active DM/JDM defined by:
* MD global VAS with a \>= 2.0 cm on a 10 cm scale and maximum value of 7.0 cm, and
* At least 2 of the following criteria:
* Patient global activity \>= 2 cm out of 10 cm visual analog scale (VAS).
* MMT-8 score of \<=138 out of 150.
* Health Assessment Questionnaire disability index with a minimum value of \>= 0.50 out of 3.0
* Elevation of at least one of the muscle enzymes (which includes creatine kinase (CK), aldolase, lactate dehydrogenase (LDH), ALT and AST) at a minimum level of 1.3X the upper limit of normal.
* Global Extramuscular disease activity score with a minimum value of \>= 1.0 cm on a 10 cm VAS scale (this measure is the physician s composite evaluation and is based on assessments of activity scores on the constitutional, cutaneous, skeletal, gastrointestinal, pulmonary and cardiac scales of the Myositis Disease Activity Assessment Tool (MDAAT).
* Physician global damage and muscle damage both \<= 5.0 cm/10 cm VAS
* If receiving prednisone and methotrexate, the dose must be stable for at least 4 weeks prior to the Week 6 visit, and daily prednisone \<= 20 mg/day.
* Background therapy with other non-corticosteroid immunosuppressive agent, if required, must be at a stable dose for at least 6 weeks prior to the Week 6 visit, except with IVIG regimen should be stable 90 days prior to the Week 6 visit and for rituximab, stable regimen for 4 months prior to Week 6.
* If an immunosuppressive agent was discontinued prior to the screening visit, then there must be a washout period before week -6 visit:
* 4-week washout for prednisone, methotrexate, and IV methylprednisolone (IV pulse therapy)
* 8-week washout for other immunosuppressive drugs, including azathioprine, mycophenolate mofetil, leflunomide, tacrolimus, cyclosporine, cyclophosphamide, colchicine, and hydroxychloroquine
* 8-week washout for IVIG
* For discontinuation of biologic or targeted drug therapies or dietary supplements, a washout prior to visit 1 (week 6) is required of 4 terminal half-lives.
* Half-lives of most common biologics and targeted drug therapies used in the treatment of DM/JDM:
* Etanercept Half-life 70 hours, Waiting period before enrollment (4 Half-lives) 12 days
* Adalimumab, Half-life, 14 days, Waiting period before enrollment (4 Half-lives) 60 days
* Rituximab, Half-life 32 days, Waiting period before enrollment (4 Half-lives) 130 days
* Infliximab, Half-life 9 days, Waiting period before enrollment (4 Half-lives) 36 days
* Abatacept, Half-life 17 days, Waiting period before enrollment (4 Half-lives) 68 days
* Anakinra, Half-life 6 hours, Waiting period before enrollment (4 Half-lives) 1 day
* Tofacitinib, Half-life 3 hours, Waiting period before enrollment (4 Half-lives) 1 day
* Baricitinib, Half-life 12hours, Waiting period before enrollment (4 Half-lives) 2 days
* Negative pregnancy test (urine or blood sample) if born female.
* Body Mass Index (BMI) \> 18 and \<= 35 kg/m\^2
* Fish intake of less than 2 servings per week on average for the past 3 months.
* Intake of meat products (beef, lamb, pork, venison, rabbit, cow s milk or dairy products) within 2 months of screening visit and of week 0 and have no reaction (no shortness of breath, hives, rash, or diarrhea) within 6 hours of ingestion of these meat products.
EXCLUSION CRITERIA:
An individual who meets any of the following criteria will be excluded from participation in this study:
* Polymyositis; inclusion body myositis; cancer-associated myositis, defined as the diagnosis of myositis within 3 years of the diagnosis of cancer, except basal or squamous cell skin cancer or carcinoma in situ of the cervix if at least 5 years since excision.
* Myositis in overlap with another autoimmune disease will be excluded under the following conditions:
i. Myositis overlapping with another autoimmune disease that precludes accurate assessment of treatment response (e.g., difficulty assessing muscle strength in a patient with scleroderma and associated myositis).
ii. Myositis overlapping with inflammatory bowel disease, including Crohn s disease, ulcerative colitis, or celiac disease.
iii. Myositis overlapping with autoimmune thyroid disease (e.g., Hashimoto s disease or Graves disease), unless the thyroid disease is
stable and well controlled with no changes in thyroid-related medications for at least 3 months prior to enrollment, in which case the
patient may be included.
* Drug- or toxin-induced myositis, including known HMG-CoA reductase autoantibody-positive necrotizing myopathy following statin use.
* Moderate to severely active myositis that would require initiation of another immunosuppressive treatment.
* Joint disease, severe calcinosis, or other musculoskeletal condition, which precludes the ability to assess/quantitate muscle strength and function.
* Concomitant illness that would prevent adequate patient assessment or in the investigators opinion pose an added risk for study participants. The investigator may consider further evaluation or consultation if clinically indicated prior to study enrollment:
* Recurrent or chronic infections, including HIV, hepatitis B and C, Epstein Barr virus, active coronavirus infection, active or recurrent gastrointestinal infection (including Helicobacter pylori), active or recurrent skin infections with calcinosis.
* Disorders that would preclude accurate assessment of neuromuscular function.
* Severe swallowing dysfunction with inability to swallow pills.
* Patients with generalized lipodystrophy.
* Severe cardiomyopathy or arrhythmias, including atrial fibrillation or atrial flutter, New York Heart Association Classification III or IV for congestive heart failure, severe interstitial lung requiring oxygen therapy, gastrointestinal vasculopathy/ulceration or gastroparesis, renal failure requiring dialysis, that in the investigators opinion poses an additional risk for study participants.
* Subjects with any acute and life-threatening condition unrelated to myositis, such as prior sudden cardiac arrest, acute myocardial infarction, stroke, embolism in last 3 months.
* History of malignancy, except basal or squamous cell skin cancer or carcinoma in situ of the cervix if at least 5 years since excision.
* Uncontrolled hypertension with average blood pressure \>= 140/90, requiring a new anti-hypertensive medication in the past 8 weeks.
* Psychiatric illness that precludes compliance or neuromuscular assessment, including major psychiatric illness requiring hospitalization within the past year and/or has had a change in depression or anxiety prescription medications within the past 3 months (by discretion of study physician).
* Subjects with chronic diarrhea, gastric bypass or lap-band procedures, ostomies, bowel motility problems, irritable bowel syndrome, symptomatic gallstones, or other conditions that could affect intestinal fat absorption.
* Subjects with clinically diagnosed hepatic disease, including but not limited to hepatitis, steatosis, cirrhosis.
* Osteoporotic fracture under therapy for pain control or impacting ambulation.
* Serum creatinine \> 2.0mg/dl or eGFR less than 50 mL/min per 1.73 m\^2.
* Subjects with coagulation or bleeding disorders (such as hemophilia) or receiving anti-platelet or anti-coagulant medications, including daily aspirin, warfarin, or Plavix.
* Life-threatening non-myositis illness that would interfere with the patient s ability to complete the study.
* Known contraindications to O3FAs, excipients or placebo contents (e.g., allergy or known hypersensitivity to that drug or its excipients, including porcine gelatin, allergies to fish or shellfish, tocopherols, glycerin, or corn). Religious or ethical reasons to not consume fish, corn and/or porcine (pork) products.
* Participants with any of the following:
* Idiopathic anaphylaxis
* Alpha-gal reaction
* Known food allergies to beef, pork, lamb or other meat products, including cow s milk and dairy products, with a history of shortness of breath, rash, or hives within 6 hours of eating these foods.
* Currently using O3FAs or consuming EPA/DHA in any form for the past 6 months.
* Currently taking supplements or medications that affect lipoproteins for the past 6 months, including fish oil supplements, bile-acid sequestrants, plant sterol supplements, PCSK9 inhibitors, fibrates, statins, or niacin.
* Use of medications or dietary supplements that interact with O3FA per pharmacy evaluation. A PharmD will evaluate the patient's current medication list for medications/supplements with the potential for significant interactions with O3FA.
* No antibiotic usage in past 3 months, as well as no usage of anti-virals, antifungals, anti-parasitics in past 3 months (except antimalarials and Paxlovid or other COVID-19 anti-viral therapy allowed).
* Subjects being treated with tamoxifen, estrogens or progestins that have not been stable for \> 4 weeks.
* Uncontrolled diabetes with HgbA1C \> 8 or hospitalization in past 6 months for diabetes.
* Uncontrolled hyperlipidemia with TC \> 400 mg/dL, TG \>150mg/dL.
* Currently on a weight-loss program
* Has experienced a weight change (gain or loss) of greater than 15 pounds or greater than 20 percent in the past 3 months
* Currently taking a GLP-1 receptor agonist medication
* No restrictive dietary habits per discretion of the study team.
* Current use of medications or dietary supplements for weight or appetite control, including laxatives or diarrheal inhibitors within the past 4 weeks.
* History of eating disorder.
* Initiation of an exercise program within 4 weeks of screening visit.
* Known or suspected history of drug or alcohol abuse within the past 6 months as determined by the medical record or patient interview.
* Blood donation in the last 6 weeks or planned blood donation during study or requiring regular blood transfusion.
* Pregnant females or nursing mothers within past 3 months, or those planning to get pregnant during the next 9 months.
* Low total WBC \< 2000, platelets \< 100,000/mm\^3; hemoglobin \< 9.5 gm/dl.
* Vitamin D level \< 20 ng/ml (at screening visit - necessitates addition of supplement and re-screen after minimum of 8 weeks).
* Subjects with TSH levels greater than 1.5X upper limit of normal or clinical evidence of hypothyroidism (at screening visit- necessitates addition of supplement and re-screen after minimum of 8 weeks).
* Participants with severe claustrophobia.
* History of or anticipated poor non-cooperation with study requirements.
* Participation in another clinical experimental therapeutic study within 30 days of screening visit or during the study.
* Hospitalization within past 30 days (other than for routine infusions).
* Prisoners or subjects who are involuntarily incarcerated.
* Resident of a nursing home, ward of the state, or institutionalized during any part of the study period.
* Persons with decisional incapacity/cognitive impairment.
* Any history or evidence of severe illness or any other condition that would make the patient, in the opinion of the investigator, unsuitable for the study.
* Participants who do not complete the ASA24 within 4 calendar days of screening will be excluded from the protocol. Additionally, participants will be excluded if their energy intake from the ASA24 is above or below established cut-off values for age and gender based on the 5th and 95th percentile of energy intakes from National Health and Nutrition Examination Survey (NHANES) data. Cut-off values for exclusion are \<600 kcal or \>4400 kcal for women and \<650 kcal and \>5700 kcal for men.
