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Effect of Aspirin and Folic Acid for Sudden Sensorineural Hearing Loss
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
The annual incidence of sudden sensorineural hearing loss (SSNHL) is 5 to 20 per 100 000 persons. The pathophysiology of SSNHL and acute vestibulo-cochlear syndromes (VCS) is unknown in more than 70% of cases. Hypothesis : an inner ear microvascular disease represents the key element in the pathogenesis of SSNHL and acute VCS. Plasma serotonin has among other tissular effect a vasospastic on microcirculation such as the inner ear microvascularisation. Increased plasma homocysteine has a deleterious effect on vascular endothelium. Inner ear microvascularisation sensitized by an increased homocysteine level and the vascular wall would vasoconstrict under serotonin stimulation inducing ischemia of the vestibular and/or cochlear organs.
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
142
Start Date
2026-04-01
Completion Date
2029-11-01
Last Updated
2026-01-14
Healthy Volunteers
No
Conditions
Interventions
Aspirin + Acid folic
Aspirin 100 mg/day and Acid Folic 5 mg/day + gold standard treatment
Placebo Aspirin + Placebo Acid folic
The Placebo Aspirin 100 mg/j + Placebo folic acid 5 mg/j + reference treatment
Locations (1)
Lariboisière Hospital
Paris, Île-de-France Region, France