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Optimal Ventilation for Cardiac Arrest
Sponsor: Children's Hospital of Philadelphia
Summary
Pediatric cardiac arrest is a life-threatening problem affecting \>15,000 hospitalized children each year. Less than half of these children survive to hospital discharge, and neurologic morbidity is common among survivors. The objective of this study is to evaluate the effectiveness of the OPTI-VENT bundle to improve survival to discharge with favorable neurological outcome (Pediatric Cerebral Performance Category Score 1-2 or no change from baseline) among children receiving at least 1 minute of CPR.
Official title: OPTImal Ventilation to Improve Pediatric Cardiac Arrest Outcomes (OPTI-VENT)
Key Details
Gender
All
Age Range
37 Weeks - 18 Years
Study Type
INTERVENTIONAL
Enrollment
1530
Start Date
2025-10-01
Completion Date
2030-03-31
Last Updated
2025-10-08
Healthy Volunteers
No
Conditions
Interventions
OPTI-VENT Bundle
Provider Education: During a brief (\<2 minute) bedside education, the educator will 1) review the CPR ventilation rate targets for age, and 2) ensure the provider has a cue card of current rate recommendations on his/her person. Compliance will be defined as performance of at least 30 trainings per unit per month. We will record provider discipline and time since last training as a surrogate of training spread. Educators will leverage these two-minute trainings to review the patient's current ventilator settings as an initial target during CPR to ensure adequate chest rise. Additionally, a focus on CPR ventilation rates will be integrated into resuscitation education or quality meetings for all disciplines. "Report cards" detailing unit-level performance will be generated by the study team for review during site monthly presentations. Point-of-Care Guidance: A metronome will be deployed to all cardiac arrests using a smart phone application.
Transition
There will be a 2-month transition period for study sites beginning study enrollment using standard ICU practices as they onboard to the study intervention.
None - control
Control - no intervention
Locations (20)
CHOC
Orange, California, United States
Lucile Packard Children's Hospital Stanford
Palo Alto, California, United States
Children's Hospital Colorado
Denver, Colorado, United States
Nemours Children's Health
Wilmington, Delaware, United States
Children's Healthcare of Atlanta
Atlanta, Georgia, United States
Riley Children's Health
Indianapolis, Indiana, United States
Stead Family Children's Hospital
Iowa City, Iowa, United States
Boston Children's Hospital
Boston, Massachusetts, United States
Washington University in St. Louis
St Louis, Missouri, United States
Cohen Children's Medical Center
New Hyde Park, New York, United States
UNC Children's Hospital
Chapel Hill, North Carolina, United States
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States
Nationwide Children's Hospital
Columbus, Ohio, United States
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
Dell Children's Medical Center
Austin, Texas, United States
Medical City Children's Hospital
Dallas, Texas, United States
UT Southwestern Medical Center
Dallas, Texas, United States
Children's Hospital of Richmond at VCU
Richmond, Virginia, United States
Seattle Children's
Seattle, Washington, United States
Children's Wisconsin
Milwaukee, Wisconsin, United States