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RECRUITING
NCT07115563
NA

Daily Amino Acid Supplementation for People With Parkinson's Disease

Sponsor: Cristina Colon-Semenza

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to learn if a tailored amino acid supplement works to help adults living with Parkinson's disease to improve nutrition, metabolic function, body composition, and physical and mental function. The main questions it aims to answer are: Does the tailored amino acid supplement increase essential amino acids (nutritional status)? Does the tailored amino acid supplement increase an antioxidant (complex amino acid) and decrease an amino acid associated with oxidative stress? Does the tailored amino acid supplement improve physical and mental health compared to a placebo supplement? Researchers will compare the tailored amino acid supplement to a placebo (a look-alike substance that contains no active ingredients) to see if the tailored amino acid supplements work to support health for people with Parkinson's disease. Participants will: Take the tailored amino acid supplement or a placebo every day for 6 months, visit the lab at baseline, after 3 months, and after 6 months for fasting blood draws, body composition assessment, and physical and mental health testing and keep a diary of their food intake and supplement intake.

Official title: Effects of Targeted Amino Acid Supplementation for People With Parkinson's Disease on Amino Acid Profiles and Health Related Markers

Key Details

Gender

All

Age Range

60 Years - 80 Years

Study Type

INTERVENTIONAL

Enrollment

30

Start Date

2025-10-31

Completion Date

2027-11

Last Updated

2025-11-13

Healthy Volunteers

No

Interventions

DIETARY_SUPPLEMENT

Targeted Amino Acid Supplement

Blend of the essential amino acids (Leucine \& Tryptophan), a conditionally essential amino acids (Arginine \& Taurine), and non-essential amino acids (Glutamate \& Tyrosine) designed to meet the unique nutritional needs of people with Parkinson's disease (PD).

DIETARY_SUPPLEMENT

Control (placebo)

The inert amino acid (alanine) will serve as an isonitrogenous control.

Locations (1)

University of Connecticut

Storrs, Connecticut, United States