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Accelerated TMS for Treatment-Resistant ECT
Sponsor: Universitair Ziekenhuis Brussel
Summary
This study investigates whether an additional treatment using transcranial magnetic stimulation (TMS) can help severely depressed patients who did not respond well to electroconvulsive therapy (ECT). All participants will first receive standard ECT treatment for depression, including brain scans (fMRI), psychological testing, clinical assessments, and the collection of blood and stool samples. If the ECT treatment is not effective, patients will be invited to participate in a second part of the study where they receive a 4-day course of accelerated TMS (20 sessions in total). The study aims to assess whether this additional TMS treatment can reduce depressive symptoms. The study also explores how brain structure, genetics, and gut health may relate to treatment success. In total, 200 patients will be included.
Official title: Accelerated dTMS Treatment for ECT-non Responders
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2025-10
Completion Date
2028-12
Last Updated
2025-08-11
Healthy Volunteers
No
Conditions
Interventions
Transcranial Magnetic Stimulation
TMS is a non-invasive brain stimulation technique
Locations (1)
UZ Brussel
Jette, Brussels Capital, Belgium