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Comparative Efficacy of IV Parecoxib vs Lidocaine in Reducing Propofol Injection Pain
Sponsor: Oman Medical Speciality Board
Summary
Propofol is the most popular IV anaesthetic agent used for induction, however one of its known side effects is causing pain on injection, the gold standard method in preventing this pain is using lidocaine prior to injecting propofol. multiple drugs have been investigated to reduce the aforementioned pain, however there has been no study comparing lidocaine to parecoxib, an NSAID.
Official title: Comparative Efficacy of Intravenous Parecoxib Versus Lidocaine in Reducing Propofol Injection Pain: A Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2025-08-01
Completion Date
2026-12-30
Last Updated
2025-08-11
Healthy Volunteers
Yes
Conditions
Interventions
Lidocaine, a local anaesthetic.
it will be given as a pretreatment prior to injection of propofol, with a tourniquet applied.
Parecoxib 40mg
atients in this group will receive IV parecoxib 40 mg (the standard full dose for an adult) diluted to a total volume of 5 mL with normal saline.