Clinical Research Directory

Inclusion Criteria: * Provision of signed and dated informed consent form * Stated willingness to comply with all study procedures and availability for the duration of the study * Persons, aged 18 years of older * Established diagnosis of exercise induced pulmonary hypertension defined by the following: 1. Invasive cardiopulmonary exercise testing demonstrating a mean pulmonary artery pressure to cardiac output (P/Q slope) greater than 3 mmHg/L/min 2. Symptoms of exertional dyspnea * Ability to perform non-invasive cardiopulmonary exercise testing, either on upright bicycle or treadmill * If childbearing age, patient must agree to use of effective contraception during the trial Exclusion Criteria: * Diagnosis of pulmonary hypertension as defined by resting mean pulmonary arterial pressure of ≥ 20 mmHg, PVR \> 3 * Severe underlying chronic lung disease (e.g. COPD, interstitial lung disease) * Underlying chronic left ventricular disease (e.g. heart failure with reduced ejection fraction) * Chronic thromboembolic disease * Pregnancy * Acute infectious symptoms including fevers within the last week * Inability or unwillingness to discontinue any phosphodiesterase 5 inhibitors or other off-label * Known allergic reactions to inhaled treprostinil * Inability to comply with study protocols