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Desflurane vs. Propofol for Cardiac Anesthesia
Sponsor: Xijing Hospital
Summary
To investigate whether the inhaled anesthetic desflurane, compared with propofol, exerts cardioprotective effects and reduces the incidence of severe postoperative major cardiac events in patients undergoing coronary artery bypass graft (CABG) surgery.
Official title: Desflurane vs. Propofol for Cardiac Anesthesia: Impact on Developing Major Cardiac Events in Patients Undergoing CABG Procedure
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
3560
Start Date
2025-10-20
Completion Date
2029-12-31
Last Updated
2025-11-25
Healthy Volunteers
No
Interventions
Desflurane group
After routine induction, maintain anesthesia with inhaled desflurane , adjusting concentration as needed to sustain 0.5-2 MAC . To maximize the cardioprotective effects of inhaled anesthetics, adhere to this intraoperative strategy: Maintain ≥1 MAC continuous desflurane for ≥30 minutes ; For on-pump CABG , discontinue desflurane 15 minutes before initiating cardiopulmonary bypass (CPB) ; If intraoperative desflurane cessation is required, implement a wash-in/wash-out strategy (recommended but non-mandatory): Perform 3 alternating cycles of: Wash-in : ≥10 minutes of desflurane at ≥0.5 MAC, Wash-out : ≥10 minutes of complete cessation of inhaled anesthetics. Propofol is strictly prohibited for anesthesia maintenance throughout the procedure , except during CPB.
Propofol group
Administer total intravenous anesthesia (TIVA) using propofol infusion at 3-8 mg/kg/h . No inhaled anesthetics are permitted for maintenance. This may be delivered via:target-controlled infusion (TCI) systems, or manual adjustment of intravenous infusion rates.
Locations (14)
Fuzhou University Affiliated Provincial Hospital
Fuzhou, Fujian, China
Cangzhou People's Hospital
Cangzhou, Hebei, China
Hebei General Hospital
Shijiazhuang, Hebei, China
The First Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China
Wuhan Asia Heart Hospital
Wuhan, Hubei, China
Jiangsu Province Hospital
Nanjin, Jiangsu, China
Xijing Hospital
Xi'an, Shaanxi, China
Sichuan Provincial People's Hospital
Chengdu, Sichuan, China
Tianjin Chest Hospital
Tianjin, Tianjin Municipality, China
Ningbo No.2 Hospital
Ningbo, Zhejiang, China
Daping Hospital, Army Medical University
Chongqing, China
Changhai Hospital
Shanghai, China
Zhongshan Hospital, Fudan University
Shanghai, China