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Multitarget Pulse Field Ablation Guided by Endocardial and Non-invasive Atrial Driver Mapping (PFA+ADM) Pilot Study. Development of an Ablation Strategy to Improve the Efficacy of Long Standing Atrial Fibrillation Ablation in Patients With High Comorbidity Burden or Heart Failure
Sponsor: Fundacion para la Innovacion en Biomedicina (FIBMED)
Summary
To assess the efficacy and safety of a percutaneous ablation strategy that targets multiple extrapulmonary structures as the Cox-Maze IV.
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2025-08
Completion Date
2027-07
Last Updated
2025-08-12
Healthy Volunteers
No
Interventions
Multitarget PFA Ablation
* Informed consent gave by the patient. * Implantable loop recorder procedure * Clinical procedure starts * Electrophysiologycal study * Non-invasive map is obtained. * Electroanatomical map of both atria is generated. * Intracavitary electrogram (EGM) driver assessment * Pulmonary vein isolation * Extra pulmonary drivers ablation based on EGM findings (rotational and high frequency sites). * Non-invasive map is obtained to assess ablation impact on driver distribution. * Remap and extra pulmonary lesions are carried out until activity. At drivers sites disappears or decreases in at least 2 hertz or up to physician criteria. * Patient follow up
Locations (1)
Hospital General Universitario Gregorio Marañon
Madrid, Madrid, Spain