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Genetic Architecture of Natriuretic Peptides and Blood Pressure Response
Sponsor: University of Alabama at Birmingham
Summary
Natriuretic peptides (NPs) are hormones produced by the heart and play an important role in maintaining cardiovascular health and have favorable metabolic benefits. Low NP levels are associated with an increased likelihood of the development of cardiometabolic diseases like diabetes and hypertension. NP levels are known to be highly heritable, with up to half of the differences in NP levels being explained by genetics. The investigators aim to describe the genetic architecture of NPs by examining the genetic variants associated with NPs, and generate and validate a polygenic score (PGS) for NPs. The investigators will use this NP PGS to examine the association of genetically determined NP levels with cardiometabolic and cardiovascular outcomes. The investigators will conduct a genotype-guided physiological clinical trial that aims to assess the genetic factors affecting NP levels and their impact on blood pressure and NP response to saline infusion, high-salt diet, and low-salt diet. These findings will help support personal medicine approaches to lower the increasing burden of hypertension in the United States.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2026-09-01
Completion Date
2030-12-01
Last Updated
2026-03-10
Healthy Volunteers
Yes
Interventions
Low Salt Diet
8 days of diet with low salt content will be given to the study participants
High Salt Diet
8 days of diet with high salt content will be given to the study participants
Saline Infusion
2 Liters of normal saline infusion (0.25 ml/kg/min over 2 hours) will be given to the study participants at the end of each study period
Locations (1)
University of Alabama at Birmingham
Birmingham, Alabama, United States