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Prognostic Value of NETosis Markers for Thrombosis During Myeloproliferative Neoplasms (AVATARE)
Sponsor: University Hospital, Bordeaux
Summary
Myeloproliferative neoplasms are hematologic diseases characterized by an increased proliferation of peripheral blood cells. The main risk of MPN is the occurrence of thrombosis. Thrombosis risk is mainly evaluated using two criteria: age and prior thrombosis. A better prediction of thrombosis risk is needed to improve prevention and treatment of MPN-associated thrombosis. The objective of the study is to evaluate the predictive value of neutrophil extracellular traps markers in thrombosis during MPN.
Official title: Prospective Study for the Evaluation of the Prognostic Value of NETosis Markers to Predict Thrombosis in Myeloproliferative Neoplasms With JAK2V617F Mutation (AVATARE)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
300
Start Date
2025-12-09
Completion Date
2030-12
Last Updated
2026-01-13
Healthy Volunteers
No
Interventions
Additional blood sampling
At inclusion (T0) and at 12 months (T1), venous blood will be drawn for plasma markers of NETosis
Locations (15)
CHU d'Angers, Service des maladies du Sang
Angers, France
CH de la Côte Basque, Service Hématologie
Bayonne, France
CHU de Bordeaux, Service Hématologie Biologique
Bordeaux, France
CHU de Bordeaux, Service Hématologie Clinique et Thérapie Cellulaire
Bordeaux, France
CHU de Brest, Service Hématologie et Hémostase Clinique
Brest, France
APHP-Hôpital Mondor, Service Hématologie Clinique et Thérapie Cellulaire
Créteil, France
CHD de Vendée, Service Onco-hématologie
La Roche-sur-Yon, France
APHP-Hôpital Bicêtre, Service Hématologie Clinique Ambulatoire
Le Kremlin-Bicêtre, France
CH de Libourne, Service Hématologie
Libourne, France
CHU de Limoges, Service Hématologie Clinique et de Thérapie Cellulaire
Limoges, France
CH des Pays de Morlaix, Service Onco-Hématologie
Morlaix, France
CHU de Nantes, Service Hématologie Clinique
Nantes, France
Hôpital Privé du Confluent, Service Hématologie
Nantes, France
APHO-Hôpital Saint-Louis, Centre d'Investigations Cliniques
Paris, France
CH de Roubaix, Service Hématologie
Roubaix, France