Clinical Research Directory

Inclusion Criteria: * Voluntary, willing to follow the protocol, able to read and understand the information form and give free and informed consent (for parents/guardian of children subjects) and assent (for subjects aged 7-14 years old); * 7-14 years old，regardless of sex; * Spherical equivalent refraction (SE) after cyclopegia ≤ -5.00 D and ≥ -9.00D; * Anisometropia and Astigmatism ≤2.50D; * Best corrected distance visual acuity of at least 0.8 in both eyes; * Willing to wear only the spectacles provided by the investigator for all days (\>10 hours) during the study without additional interventions; * Accept randomization; * Able to sign the informed consent form with the accompaniment and understanding of parents or guardians. Exclusion Criteria: * Allergic or intolerant to cycloplegic drugs； * Exclude children on high dose atropine (1%) or red light therapy； * Any previous history of myopia control treatment in the previous 30 days, like low dose atropine, defocus spectacles, or thokeratology and acupuncture； * History or presence of an ocular disease, strabismus or amblyopia or other binocular vision abnormalities, accommodation dysfunction, and cataract.； * History of eye surgery； * Ocular or systemic diseases that may be associated with myopia, such as Marfan syndrome, retinopathy of newborns, diabetes, etc； * Anatomic or skin factors affecting the wearing of spectacles； * Other conditions unsuitable for inclusion (patients with excessive expectations for the effect of the defocus spectacle lenses or desires to try other myopia interventions).