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Optimizing Metformin Use in Polycystic Ovary Syndrome
Sponsor: Helsinki University Central Hospital
Summary
The goal of this clinical trial is to learn if a metformin dose of 1500 mg or 2250 mg per day is better to treat polycystic ovary syndrome (PCOS) in adults. It will also learn about the adverse effects of metformin. The trial aims to evaluate which metformin dose is better for: 1. improving biochemical and clinical outcomes 2. gastrointestinal side-effects 3. mental health and quality of life Participants will: * Be randomized to take metformin at a dose of either 1500mg or 2250mg every day for 6 months * Visit the clinic three times during the trial for checkups and tests * Answer questionnaires on menstrual cyclicity, mental health, quality of life and side-effects
Official title: Optimizing Metformin Use in Polycystic Ovary Syndrome - A Randomized Controlled Trial
Key Details
Gender
FEMALE
Age Range
18 Years - 37 Years
Study Type
INTERVENTIONAL
Enrollment
184
Start Date
2025-09-01
Completion Date
2028-12-31
Last Updated
2025-08-13
Healthy Volunteers
No
Conditions
Interventions
Metformin 1500 mg daily
metformin 500mg tablets, 3 times per day
Metformin 2250 mg daily
Metformin 750mg, 3 times daily
Locations (1)
The Reproductive Medicine Unit, Helsinki University Hospital
Helsinki, Finland