Clinical Research Directory

Inclusion Criteria: * Age 44 to 55 years * Not severely obese (BMI \<35 kg/m\^2) * Healthy (determined by a screening questionnaire, physical and medical history by a certified nurse practitioner, complete metabolic panel, and complete blood count) * Willing to include prunes in their daily diet * Not taking any natural dietary supplement containing phenolics, i.e.,\< 1 cup/day of blueberries or apples for at least 2 months prior to study entry * Non-smoking * Ambulatory * No menses for ≥60 days but not more than 18 months post final menstrual period * Only participants who have a determinable natural (not surgical) final menstrual period date are eligible Exclusion Criteria: * Subjects who regularly consume prunes, dried apples, prune juice, or heavy consumers of blueberries (1 cup or more/day) * History of vertebral fracture or fragility fracture of the wrist, humerus, hip or pelvis after age 45 yr) * Untreated hyper- or hypothyroidism * Current hyper- or hypoparathyroidism * Significantly impaired renal function * Current hypo- or hypercalcemia * History of spinal stenosis * History of heart attack, stroke, thromboembolism, kidney disease, malabsorption syndrome, or seizure disorders * Positive for HIV, Hep-C or Hep-B surface antigen and malignancy * Use of the following agents affecting bone metabolism: intravenous bisphosphonates at any time; fluoride (for osteoporosis) within the past 24 months; denosumab at any time; bisphosphonates, parathyroid hormone or strontium within the past 12 months; calcitonin; selective estrogen receptor modulators within the past 12 months; systemic oral or transdermal estrogen within the past 3 months; systemic glucocorticosteroids (≥ 5 mg prednisone equivalent per day for more than 10 days); or tibolone within the past 3 months * Hormonal contraception within the past three months * Subjects who will not consume study provided dietary items or who will not stop taking their own natural product supplements