Clinical Research Directory

Inclusion Criteria: 1. Male or female patients aged between 18 and 75; 2. Radiographic evidence of bilateral OA of the knees graded between 2 and 4 on the Kellgren-Lawrence scale; 3. Pain equal to or greater than 4 on the Numeric Rating Scale (NRS) for both knees; 4. Failure, defined as persistence of symptoms after at least 6 months of conservative treatment (pharmacological, physiotherapy, or infiltration treatment); 5. Ability and willingness to undergo the study procedures and comply with the instructions given by the study team; 6. No history of 4\. Failure, defined as persistent symptoms, after at least 6 months of conservative treatment (pharmacological, physiotherapy, or infiltration treatment); 5. Ability and consent of patients to actively participate in the rehabilitation and follow-up protocol; 6. Signature of informed consent Exclusion Criteria: 1. Patients incapable of understanding and willing; 2. Diagnosis of active neoplasia; 3. Diagnosis of rheumatoid arthritis, Reiter's syndrome, psoriatic arthritis, gout, ankylosing spondylitis, or arthritis resulting from another inflammatory disease; human immunodeficiency virus (HIV) infection, active viral hepatitis; chondrocalcinosis; 4. Patients with uncontrolled diabetes mellitus; 5. Patients with uncontrolled thyroid metabolic disorders; 6. Patients who abuse alcohol, drugs, or medications; 7. Patients with lower limb misalignment greater than 5°; 8. Body Mass Index \> 35 kg/m2; 9. Pregnancy or breastfeeding, or plans to become pregnant during the study period . 10. Patients with a history of trauma or intra-articular infiltration of therapeutic substances in the 6 months prior to screening. 11. Patients who have undergone knee surgery in the 12 months prior to screening. 12. Patients with insufficient abdominal adipose tissue, as assessed by the investigator.