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Neural Contributions to Exercise-Induced Hypoalgesia With Blood Flow Restriction
Sponsor: University of Gran Rosario
Summary
This experimental study explores the neurophysiological mechanisms associated with pain modulation following a single session of low-intensity resistance exercise combined with BFR in healthy young adults. The study evaluates changes in sensory thresholds before and after the intervention using validated quantitative sensory testing (QST) methods. These include pressure pain thresholds, conditioned pain modulation, thermal thresholds, and temporal summation. The findings may contribute to a better understanding of the role of the nervous system in exercise-induced hypoalgesia, particularly in response to BFR protocols, with implications for future research in pain and rehabilitation.
Official title: Exploration of Neurophysiological Mechanisms of Exercise-Induced Hypoalgesia With Blood Flow Restriction in Healthy Adults
Key Details
Gender
All
Age Range
18 Years - 35 Years
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2025-08-04
Completion Date
2025-10
Last Updated
2025-08-19
Healthy Volunteers
Yes
Conditions
Interventions
Low-Intensity Resistance Training with BFR
Warm-up: Five minutes of light-intensity cycling on a stationary bike. Exercises: 1. Bilateral half squat (0°-90°) 2. Single-leg step-down from a 20 cm step 3. Knee extension (90°-0°) at 30% of one-repetition maximum (1RM) 4. Single-leg shallow squat (0°-45°) Protocol: One set of 30 repetitions (or until volitional fatigue) followed by three sets of 15 repetitions for each exercise. Rest periods: One minute between sets and two minutes between exercises. BFR Application: Pneumatic cuff (The Occlusion Cuff Pro®) placed proximally on the dominant thigh, inflated to 60% of complete arterial occlusion (determined via Doppler ultrasound). The cuff remains inflated during sets and rest periods, and is deflated after completion of each exercise.
Locations (1)
University Center for Assistance, Teaching and Research (CUADI)
Rosario, Santa Fe Province, Argentina