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Characterization of Gut and Tongue Coating Microbiota in Patients With Diminished Ovarian Reserve
Sponsor: Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University
Summary
The goal of this observational study is to investigate the distinct tongue manifestation characteristics in patients with diminished ovarian reserve (DOR) compared to healthy individuals, and to clarify the features of tongue coating microbiota, gut microbiota, and their interrelationships in DOR patients. The main question it aims to answer is: Whether there are significant differences in tongue manifestations, tongue coating microbiota, and gut microbiota characteristics between DOR patients and healthy populations; Whether associations exist between tongue coating microbiota and gut microbiota in DOR patients; Whether the pathogenesis of DOR may influence estrogen metabolism through alterations in oral and gut microbiota.
Official title: Dysbiosis of Gut-Tongue Coating Microbiota Crosstalk and Its Clinical Association With Diminished Ovarian Reserve: A Microbiome-Based Case-Control Study
Key Details
Gender
FEMALE
Age Range
20 Years - Any
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2025-01-28
Completion Date
2025-12-31
Last Updated
2025-08-26
Healthy Volunteers
Yes
Conditions
Interventions
gut microbiota
Fresh fecal samples were collected from patients during the non-menstrual period and subjected to 16S rDNA sequencing.
tongue coating microbiota
Tongue coating samples were collected under fasting conditions between 6:00-9:00 AM on the same day as fecal specimen collection and subjected to 16S rDNA sequencing.
tongue picture
Tongue images were captured under fasting conditions between 6:00-9:00 AM on the same morning as fecal specimen collection.
Locations (1)
Hangzhou TCM Hospital of Zhejiang Chinese Medical University
Hangzhou, Zhejiang, China