Clinical Research Directory

Inclusion Criteria: * Clinical history of Type 1 Diabetes with \> 5 years of duration * 2-hour C-peptide level \<0.3 ng/mL after a mixed meal stimulation test * Under continuous insulin therapy, Participants have at least one of the following conditions: 1. At least one episode of documented severe hypoglycemia in the 12 months prior to enrollment; 2. Unaware hypoglycemia evaluated using the Clarke scoring system * Willing and able to conduct self-blood glucose monitoring as required, with good compliance * Voluntarily participate and sign the informed consent form Exclusion Criteria: * Uncontrolled systemic infections, including but not limited to pulmonary tuberculosis, active hepatitis, a history of positive hepatitis B surface antigen (HBsAg), hepatitis C virus antibody (HCV-Ab), human immunodeficiency virus antibody (HIV-Ab), or Treponema pallidum antibody (TP-Ab). * History of malignancy within the past 5 years or undergoing antitumor treatment * Participation in other clinical trials in the 3 months or islet cell transplant, organ transplant, or cell therapy in the 12 months prior to enrollment * Other situations judged by the investigator as unsuitable for participation in the trial