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Ketones for Opioid Craving
Sponsor: University of Maryland, Baltimore
Summary
The goal of this clinical trial is to learn if ketone supplementation (KS) works to reduce craving for opioids for adults with opioid use disorder (OUD) undergoing in-patient acute withdrawal management. The main questions it aims to answer are: * Does KS reduce craving for opioids in patients with opioid use disorder? * Does KS reduce symptoms of opioid withdrawal such as low mood and pain? Researchers will compare KS to a placebo to see if KS works to reduce craving for opioids and reduce withdrawal symptoms in adults entering in-patient acute withdrawal management for opioid use disorder. Participants will: * Be given KS or a placebo three (3) times daily for seven (7) days * Complete mood, pain tolerance, and subjective opioid withdrawal assessments
Official title: Ketone Supplementation for Opioid Craving and Withdrawal
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2026-05
Completion Date
2027-09
Last Updated
2026-03-13
Healthy Volunteers
No
Conditions
Interventions
Treatment with Ketone Supplement
Participants (n=25) will receive three doses of a ketone supplement drink daily for seven days.
Treatment with Placebo
Participants (n=25) will receive three doses of a placebo drink for seven days.
Locations (1)
Caron Pennsylvania Addiction Treatment and Rehab Center
Wernersville, Pennsylvania, United States