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Intermittent-Hypoxia Inhibits Neutrophil Extracellular Traps Formation: Role of Cathelicidins
Sponsor: Kun-Ta Chou
Summary
The study will enroll 80 moderate-to-severe Obstructive sleep apnea (OSA) patients (40 obese) and 40 age-, gender-, and body mass index-matched controls. Venous blood will be collected to isolate neutrophils, which will be tested for the ability to produce neutrophil extracellular traps (NETs) along with the levels of LL-37 and NETs products in the blood. Measurements will be repeat after three months treatment for OSA.
Key Details
Gender
All
Age Range
20 Years - Any
Study Type
OBSERVATIONAL
Enrollment
120
Start Date
2025-09
Completion Date
2028-07
Last Updated
2025-09-11
Healthy Volunteers
Yes
Conditions
Interventions
CPAP
Continuous positive airway pressure (CPAP) is the standard treatment for moderate to severe OSA in clinical practice.
Locations (1)
Taipei Veterans General Hospital
Taipei, Taipei, Taiwan