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RECRUITING
NCT07131059
NA

MRD-positive AML Clinical Study

Sponsor: Institute of Hematology & Blood Diseases Hospital, China

View on ClinicalTrials.gov

Summary

This clinical trial is a platform-type clinical study intended to investigate the efficacy and safety of MRD-positive acute myeloid leukemia patients after comprehensive treatment, which includes but is not limited to the following drugs and protocols: Chemotherapy, small molecule targeted drugs, demethylation drugs, liposome drugs and the combination of these drugs to form a combination of treatment regimen, the specific treatment regimen will be updated according to the results of this trial and the latest research progress at home and abroad.

Official title: MRD-positive AML: a Prospective, Single-arm, Multicenter Platform Clinical Study

Key Details

Gender

All

Age Range

14 Years - Any

Study Type

INTERVENTIONAL

Enrollment

120

Start Date

2024-05-11

Completion Date

2028-04-30

Last Updated

2025-08-20

Healthy Volunteers

No

Conditions

Interventions

DRUG

Ivosidenib

500mg d1-28

DRUG

Gilteritinib

120mg d1-28

DRUG

Venetoclax

400mg d1-21 ; 400mg d1-7;400mg d1-28; 600mg d1-21

DRUG

Avapritinib

200mg d1-28.

DRUG

Daunorubicin

45mg/m2/d d1-2;

DRUG

Cytarabine

100mg/m2/d d1-5

DRUG

Idarubicin

10mg/m2/d d1-2

DRUG

MTZ

8mg/m2/d d1-2

DRUG

HHT

2mg/m2/d d1-5

DRUG

Azacitidine

75mgd/m2 d1-7.

Locations (1)

Blood Diseases Hospital

Tianjin, Tianjin Municipality, China