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MRD-positive AML Clinical Study
Sponsor: Institute of Hematology & Blood Diseases Hospital, China
Summary
This clinical trial is a platform-type clinical study intended to investigate the efficacy and safety of MRD-positive acute myeloid leukemia patients after comprehensive treatment, which includes but is not limited to the following drugs and protocols: Chemotherapy, small molecule targeted drugs, demethylation drugs, liposome drugs and the combination of these drugs to form a combination of treatment regimen, the specific treatment regimen will be updated according to the results of this trial and the latest research progress at home and abroad.
Official title: MRD-positive AML: a Prospective, Single-arm, Multicenter Platform Clinical Study
Key Details
Gender
All
Age Range
14 Years - Any
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2024-05-11
Completion Date
2028-04-30
Last Updated
2025-08-20
Healthy Volunteers
No
Conditions
Interventions
Ivosidenib
500mg d1-28
Gilteritinib
120mg d1-28
Venetoclax
400mg d1-21 ; 400mg d1-7;400mg d1-28; 600mg d1-21
Avapritinib
200mg d1-28.
Daunorubicin
45mg/m2/d d1-2;
Cytarabine
100mg/m2/d d1-5
Idarubicin
10mg/m2/d d1-2
MTZ
8mg/m2/d d1-2
HHT
2mg/m2/d d1-5
Azacitidine
75mgd/m2 d1-7.
Locations (1)
Blood Diseases Hospital
Tianjin, Tianjin Municipality, China