Clinical Research Directory

Inclusion Criteria: * Aged ≥45 years and \<60 years; Frailty status assessed by Fried phenotype criteria, including those diagnosed with frailty or pre-frailty; Meeting AHA guideline criteria for Stage 1-2 CKM syndrome (diagnostic details in Table 1); Ability to communicate normally and use smartphones or wearable devices; Willingness to participate in surveys and follow-up; Additional Note on PREVENT Equation: The PREVENT equation, developed by the American Heart Association (AHA), is a cardiovascular disease (CVD) risk prediction tool. It calculates 10-year CVD risk based on: Age, sex Total cholesterol, HDL-C Systolic blood pressure, BMI eGFR History of diabetes, smoking Use of antihypertensive or lipid-lowering medications Exclusion Criteria: * Severe cognitive impairment (e.g., MMSE score \<10 or clinical dementia diagnosis); Severe psychiatric/psychological disorders (e.g., schizophrenia, major depressive disorder with suicidal ideation); Advanced chronic diseases including: End-stage renal disease (eGFR \<15 mL/min/1.73m² or on dialysis) Metastatic cancer (stage IV per AJCC criteria) Cardiorespiratory insufficiency (NYHA Class III-IV heart failure or COPD GOLD Stage D) Severe osteoarthritis (Kellgren-Lawrence Grade 4 with functional limitation) Major surgery or acute illness within 3 months (e.g., myocardial infarction, stroke, or major trauma requiring hospitalization); Physical disabilities impairing mobility (e.g., amputation, paralysis, or severe Parkinsonism with Hoehn \& Yahr Stage ≥3).