Clinical Research Directory
Browse clinical research sites, groups, and studies.
Secondary Mitral Regurgitation Treatment With MitraClip and Assessment by Cardiac Magnetic Resonance
Sponsor: Minneapolis Heart Institute Foundation
Summary
This is a multi-center, prospective, observational study designed to evaluate the impact of LV myocardial fibrosis extent assessed by CMR on LV reverse remodeling and clinical outcomes post TEER. The target sample will be up to 125 patients enrolled to achieve 100 evaluable at 6 months of follow-up. Enrollment will occur at up to eight centers.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
125
Start Date
2022-03-03
Completion Date
2027-07
Last Updated
2025-12-23
Healthy Volunteers
No
Interventions
Cardiac MRI
Clinically indicated baseline CMR study with contrast up to 90 days before TEER procedure, including KCCQ questionnaire. At 6 months, participants will return for repeat of KCCQ, CMR study and a transthoracic echocardiogram. Blood samples, done as standard clinical care for hemotocrit for ECV calculation, will be obtained.
Locations (6)
Minneapolis Heart Institute Foundation
Minneapolis, Minnesota, United States
Sanger Heart and Vascular Institute
Charlotte, North Carolina, United States
The Christ Hospital Health Network
Cincinnati, Ohio, United States
Cleveland Clinic
Cleveland, Ohio, United States
Inova Fairfax Medical Campus
Falls Church, Virginia, United States
IRCCS Ospedale San Raffaele
Milan, Italy