Clinical Research Directory

A Waist Circumference and Body Fat Percentage Dual-Dimension Nine-Square Grid Model for Precision Obesity Management: A Randomized Controlled Trial in Overweight/Obese University Students

Sponsor: Hainan Normal University

Summary

This single-center, two-arm, parallel exploratory randomized controlled trial compared adaptive multicomponent weight management guided by a 3×3 waist circumference-body fat percentage (WC-BFP) phenotype classification with structured aerobic exercise over 8 weeks. Forty-eight university students with overweight, central obesity, or elevated BFP were randomized 1:1. The adaptive intervention combined aerobic, resistance, and flexibility exercise with phenotype-matched nutritional and behavioral support; WC and BFP were reassessed every 2 weeks to guide prescription adjustments. The comparator involved 3-5 aerobic exercise sessions per week, totaling more than 150 minutes per week, with progressive intensity from 40%-50% to 60%-80% of heart rate reserve. Both groups received individualized minimum daily energy-intake targets, wearable monitoring, online exercise and dietary logging, and remote supervision. Anthropometric outcomes and exercise self-efficacy were assessed at baseline and weeks 4 and 8; exercise adherence was assessed at weeks 4 and 8. The manuscript identifies week-8 body weight as the primary outcome, five additional anthropometric measures as secondary outcomes, and behavioral measures and phenotype transitions as supportive or exploratory outcomes.

Official title: Adaptive Weight Management Guided by a 3×3 WC-BFP Phenotype in University Students With Overweight or Obesity: An Exploratory Randomized Controlled Trial

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