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NOT YET RECRUITING
NCT07133932
NA

Phrenic Nerve Stimulation for Reducing Ventilation Duration in Acute Cerebral Infarction: A Multicenter Randomized Controlled Trial

Sponsor: Xuanwu Hospital, Beijing

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to learn if non-invasive phrenic nerve stimulation works in adult acute cerebral infarction participants undergoing mechanical ventilation. It will also learn about the safety of non-invasive phrenic nerve stimulation. The main questions it aims to answer are: 1. Can non-invasive phrenic nerve stimulation shorten the duration of ventilator use and improve long-term prognosis? 2. What medical problems do participants have when taking non-invasive phrenic nerve stimulation? Researchers will compare non-invasive phrenic nerve stimulation to a sham stimulation to see if non-invasive phrenic nerve stimulation works. Participants will: 1. Receive 14 days of non-invasive phrenic nerve stimulation or sham stimulation 2. Visit the clinic or call for follow-up at 90 days of onset

Official title: Transcutaneous Electrical Phrenic Nerve Stimulation for Reducing Mechanical Ventilation Duration in Acute Cerebral Infarction: A Multicenter Randomized Controlled Trial

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

590

Start Date

2025-09-01

Completion Date

2027-12-31

Last Updated

2025-08-21

Healthy Volunteers

No

Interventions

DEVICE

Transcutaneous electrical phrenic nerve stimulation

Non-invasive transcutaneous electrical phrenic nerve stimulation which can cause explicit contraction of the diaphragm, and the stimulation current may be set to 5-30mA depending on the participant's condition.

DEVICE

Sham (No Treatment)

The stimulation current is set to 0.

Locations (9)

Xuanwu Hospital Capital Medical University

Beijing, Beijing Municipality, China

The First Hospital of Heibei Medical University

Shijiazhuang, Hebei, China

Beijing Ditan Hospital, Capital Medical University

Beijing, China

Beijing Hui Min Hospital

Beijing, China

Sanbo Brain Hospital, Capital Medical University

Beijing, China

Dongzhimen Hospital Beijing University of Chinese Medicine

Beijing, China

Beijing Tongren Hospital, Capital Medical University

Beijing, China

The First Hospital of Fangshan District

Beijing, China

Beijing Daxing District People's Hospital

Beijing, China