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Vaped Phenanthrene
Sponsor: University of Minnesota
Summary
Some people who used to smoke cigarettes continue to be at higher risk of developing lung cancer, even years after quitting. This study will look to see if a specific chemical, phenanthrene, is broken down in the lungs of former smokers through more harmful pathways than never-smokers. If former smokers break down chemicals that enter their lungs through more harmful pathways this might be putting them at higher risk for developing lung cancer even though they quit smoking. This information may help find better ways to prevent or treat cancer in the future. This study is under an IND, but the drug is not being studied; instead, it is being used as a marker for drug metabolism.
Official title: Investigating Vaped Phenanthrene Biomarkers in Former Smokers
Key Details
Gender
All
Age Range
21 Years - Any
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2026-05-01
Completion Date
2028-06-30
Last Updated
2026-04-03
Healthy Volunteers
Yes
Conditions
Interventions
D10-phenanthrene
All study participants (Former Daily Smokers and Non-smokers) will be asked to vape D10-phenanthrene to see how their lungs breakdown a class of cancer-causing chemicals known as polycyclic aromatic hydrocarbons \[PAHs\].
Locations (1)
University of Minnesota
Minneapolis, Minnesota, United States