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Risk of Acute Kidney Injury in Pulmonary Endarterectomy
Sponsor: China-Japan Friendship Hospital
Summary
This study aims to assess the perioperative risk factors for acute kidney injury (AKI) in patients undergoing pulmonary endarterectomy (PEA) with deep hypothermic circulatory arrest (DHCA). By analyzing retrospective data (2016-2025) from approximately 240 PEA patients and prospectively enrolling 44 patients (2025-2027), we will identify clinical risk factors, establish and validate a comprehensive prediction model, and explore the dynamic characteristics and predictive value of novel biomarkers (e.g., NGAL, KIM-1). The goal is to improve early warning and management of PEA-related AKI, thereby enhancing patient outcomes.
Official title: Perioperative Risk Assessment of Acute Kidney Injury Related to Pulmonary Endarterectomy Under Deep Hypothermic Circulatory Arrest
Key Details
Gender
All
Age Range
18 Years - 85 Years
Study Type
OBSERVATIONAL
Enrollment
284
Start Date
2026-01-01
Completion Date
2029-07-30
Last Updated
2025-08-22
Healthy Volunteers
No
Conditions
Locations (1)
China-Japan Friendship Hospital
Beijing, Beijing Municipality, China