Clinical Research Directory

Inclusion Criteria: * Must be undergoing a primary ACLR with or without the following: * Chondroplasty * Synovectomy * Loose body removal * Removal of hardware * Meniscal surgery (excluding meniscal allograft transplantation/MAT) * Lateral extra-articular tenodesis * Must have skeletal maturity in the distal femur and proximal tibial physes * Must be age 18 years or older at time of enrollment Exclusion Criteria: * \<18 years at time of enrollment * No diagnosis of ACL tear * ACL repairs * Revision ACL reconstructions * Open distal femur or proximal tibia physes * Major concomitant procedures (such as osteotomy, MAT, or cartilage restoration surgery) * History of prior proximal or distal femur fracture (including those receiving nonoperative treatment) * History of prior ipsilateral femur or tibia osteomyelitis * Medical history * History of hypotensive disease, including postural orthostatic hypotension syndrome (POTS), autonomic dysreflexia, or Shy-Drager syndrome (aka multiple system atrophy), baseline hypotension \<90 systolic or \<60 diastolic mmHg. * History of significant hepatic disease (liver transplantation, cirrhosis of any cause, or any liver disease with Child-Pugh classification B or C) due to hepatic metabolism of ARBs. * Chronic kidney disease * Rheumatologic disorders on immunologic medications * Current medications including diuretics (i.e. furosemide), lithium, and spironolactone * Current hypertension with prescription of an ARB or ACE-I * Allergy to losartan * Current pregnancy or breastfeeding