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RECRUITING
NCT07136285
PHASE1/PHASE2

Olvi-Vec Combined With Platinum Plus Etoposide Therapy in Patients With Late Phase SCLC

Sponsor: Newsoara HYK Biopharmaceutical (Shanghai) Co., Ltd.

View on ClinicalTrials.gov

Summary

Oncolytic virus product named Olvi-Vec combined with Platinum plus Etoposide in patients with late phase SCLC

Official title: PIb/II, Open-label, Multicenter Study to Evaluate the Safety, Tolerability and Efficacy of I.V. Olvi-Vec Combined With Platinum Plus Etoposide in Patients With Advanced SCLC Who Are Platinum-recurrent or Platinum-refractory

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

27

Start Date

2023-07-24

Completion Date

2026-12

Last Updated

2025-12-03

Healthy Volunteers

No

Interventions

DRUG

Olvi-Vec

Olvi-Vec will be administered to patient for 3 days during C1

DRUG

platinum (cisplatin or carboplatin)

After completing the first cycle of treatment of Olvi-Vec (+21 days after the last dose), Platinum (Carboplatin or Cisplatin)will be administrated on D1,D2 and D3 each 21 days (dosage according to the label) from Cycle 2 until disease progression or intolerable toxicity occurred.

DRUG

Etoposide

After completing the first cycle of treatment of Olvi-Vec (+21 days after the last dose), Etoposide will be administrated on D1,D2 and D3 each 21 days (dosage according to the label) from Cycle 2 until disease progression or intolerable toxicity occurred.

Locations (2)

Zhejiang Provincial People's Hospital

Hangzhou, China

Shanghai chest hospital

Shanghai, China