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Olvi-Vec Combined With Platinum Plus Etoposide Therapy in Patients With Late Phase SCLC
Sponsor: Newsoara HYK Biopharmaceutical (Shanghai) Co., Ltd.
Summary
Oncolytic virus product named Olvi-Vec combined with Platinum plus Etoposide in patients with late phase SCLC
Official title: PIb/II, Open-label, Multicenter Study to Evaluate the Safety, Tolerability and Efficacy of I.V. Olvi-Vec Combined With Platinum Plus Etoposide in Patients With Advanced SCLC Who Are Platinum-recurrent or Platinum-refractory
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
27
Start Date
2023-07-24
Completion Date
2026-12
Last Updated
2025-12-03
Healthy Volunteers
No
Conditions
Interventions
Olvi-Vec
Olvi-Vec will be administered to patient for 3 days during C1
platinum (cisplatin or carboplatin)
After completing the first cycle of treatment of Olvi-Vec (+21 days after the last dose), Platinum (Carboplatin or Cisplatin)will be administrated on D1,D2 and D3 each 21 days (dosage according to the label) from Cycle 2 until disease progression or intolerable toxicity occurred.
Etoposide
After completing the first cycle of treatment of Olvi-Vec (+21 days after the last dose), Etoposide will be administrated on D1,D2 and D3 each 21 days (dosage according to the label) from Cycle 2 until disease progression or intolerable toxicity occurred.
Locations (2)
Zhejiang Provincial People's Hospital
Hangzhou, China
Shanghai chest hospital
Shanghai, China