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Immune Dynamics in the Natural History of Chronic HBV Infection
Sponsor: Nanfang Hospital, Southern Medical University
Summary
The purpose of this observational study is to follow up on chronic HBV-infected patients over a long period of time to understand the changes in the immune status as age increases and the natural history of chronic HBV infection progresses. The main questions it aims to answer are: * Does the natural history of chronic HBV infection progress with changes in HBV-specific immunity? * What is the role of age in the natural history of chronic HBV infection? Patients with chronic HBV infection who are untreated and aged 1-80 years will be followed up every six months. During each follow-up, HBV-related serological and virological indicators will be tested. Peripheral blood samples will also be collected to test HBV-specific immunity and the immune environment.
Key Details
Gender
All
Age Range
1 Year - 80 Years
Study Type
OBSERVATIONAL
Enrollment
5000
Start Date
2024-02-01
Completion Date
2041-12-01
Last Updated
2025-09-30
Healthy Volunteers
No
Interventions
Venipuncture
For adults (including those who are 18 years old): During the routine follow-up visits, an extra 30 milliliters of peripheral blood will be drawn. For minors (under 18 years old): During the routine follow-up visits, an extra 6 milliliters of peripheral blood will be drawn. Follow-ups will be conducted every six months, with a minimum of six visit points.
Locations (1)
Nanfang Hospital, Southern Medical University
Guangzhou, Guangdong, China