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Optimizing Linezolid Dosing in Patients With Advanced Renal Impairment: a Therapeutic Drug Monitoring-based Evaluation
Sponsor: Alexandria University
Summary
The goal of this clinical trial is to adjust the Linezolid dose according to its blood level in adults with kidney diseases. It will also learn about the safety of linezolid. The main questions it aims to answer are: * How often does linezolid require level monitoring? * How often does linezolid require dose adjustment? * What medical benefits do participants have when linezolid level monitoring is applied? Researchers will compare two dose reduction regimens when they have evidence of overexposure to determine which regimen is more effective in preventing thrombocytopenia (Platelet drop). Participants will: * Withdrew linezolid level every 2 to 4 days of the antibiotic course. * Visit the clinic twice for checkups and tests.
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2025-10-15
Completion Date
2026-05-15
Last Updated
2025-08-24
Healthy Volunteers
No
Conditions
Interventions
Linezolid (IV and PO)
No dose change and continued linezolid 600 mg every 12 hours.
Linezolid (IV and PO)
Intervention and adjustment of the linezolid dose from 600 mg every 12 hours to 300 mg every 12 hours.
Linezolid (IV and PO)
Intervention and adjustment of the linezolid dose from 600 mg every 12 hours to 600 mg every 24 hours.