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Research on the Application of 99mTc-TCR-FAPI SPECT Imaging in Rheumatoid Arthritis
Sponsor: Luo Yaping
Summary
This study proposes to evaluate 99mTc-CTR-FAPI SPECT imaging as a cost-effective, low-radiation, and widely accessible alternative to 68Ga-FAPI PET/CT for assessing synovial lesions in RA patients, aiming to validate its diagnostic consistency with both PET/CT and physical examinations while correlating imaging findings with clinical disease activity metrics to establish a practical tool for long-term RA monitoring.
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2025-05-10
Completion Date
2028-04-28
Last Updated
2025-08-24
Healthy Volunteers
No
Conditions
Interventions
68Ga-FAPI PET/CT and 99mTc-CTR-FAPI SPECT
For 68Ga-FAPI PET/CT scan，each patient was injected with 1.8-2.2 MBq/kg (0.05-0.06 mCi/kg) body weight of 68Ga-FAPI. PET/CT from skull to feet was performed 60±5 min post-injection. For 99mTc-CTR-FAPI SPECT scan:each patient was injected with 10-20mCi 99mTc-CTR-FAPI . Planar SPECT scan and SPECT/CT were performed 60±5 min post-injection.
Locations (1)
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China