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Short-term Low-dose Low-molecular-weight Heparin to Prevent Postpartum Thrombosis
Sponsor: Marc Blondon
Summary
The goal of this clinical trial is to evaluate the risk-benefit of a short-term treatment with a low-dose low-molecular-weight heparin (LMWH), in the postpartum period (after delivery). The main questions it aims to answer are: * compared to no treatment, does short-term postpartum LMWH modify the risk of venous thromboembolism within 90 days of delivery? * compared to no treatment, does short-term postpartum LMWH modify the risks of bleeding and wound complications? Participants will take low-dose LMWH for 7-10 days or no treatment, and will be followed for 90 days post-delivery.
Official title: Short-term Low-dose Low-molecular-weight Heparin to Prevent Postpartum Thrombosis: a Pragmatic, Multi-center, Open-label Randomized Controlled Study
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
9200
Start Date
2025-10-15
Completion Date
2030-08
Last Updated
2026-07-24
Healthy Volunteers
No
Conditions
Interventions
Low-dose low-molecular-weight heparin
Low-molecular-weight heparin given for 7-10 days after delivery: * enoxaparin 4000-6000IU o.d. * nadroparin 3800-5700IU o.d. * dalteparin 5000-7500IU o.d. * tinzaparin 4500-7000IU o.d.
Locations (8)
Kantonsspital Baden
Baden, Switzerland
Universitätsspital Basel
Basel, Switzerland
Lindenhofspital
Bern, Switzerland
Geneva University Hospitals
Geneva, Switzerland
Centre Hospitalier Universitaire Vaudois
Lausanne, Switzerland
Ente Ospedaliero Cantonale
Lugano, Switzerland
Réseau Hospitalier Neuchâtelois
Neuchâtel, Switzerland
Hôpital du Valais
Sion, Switzerland