Clinical Research Directory

Inclusion Criteria: 1. Age≥18 years； 2. Within 24 hours of presenting to the emergency department (ED) with chest pain or other symptoms suggestive of coronary artery disease (CAD)； 3. HEART-score \>3 (according to http://www.heartscore.nl/)； 4. Signed written informed consent. Exclusion Criteria: 1. Inability to obtain informed consent； 2. Acute Coronary Syndromes (ACS) requiring urgent revascularization； 3. Known Obstructive Coronary Artery Disease (CAD) or previous PCI or CABG; 4. Concomitant severe congestive heart failure (New York Heart Association \[NYHA\] class III-IV or left ventricular ejection fraction \[LVEF\] \< 30%) or acute pulmonary edema; 5. Severe hepatic insufficiency (Child-Pugh score ≥ C, or aspartate aminotransferase \[AST\] \> 5× upper limit of normal); severe renal insufficiency (estimated glomerular filtration rate \[eGFR\] ≤ 30 mL/min/1.73 m²) or patients receiving continuous renal replacement therapy, hemodialysis, or peritoneal dialysis; 6. History of prior coronary artery bypass grafting (CABG); 7. Severe allergy to iodinated contrast agents; 8. Inability to obtain high-quality imaging; 9. Pregnant or lactating females; 10. Concomitant diseases or limited life expectancy, quality of life, or functional status precluding further CAD evaluation; 11. Any other factors that, in the investigator's judgment, make the patient unsuitable for study enrollment, completion of the study, or follow-up.