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Effect of Systemic Retinoic Acid Use on Micro Ribonucleic Acid (mRNA) Expression
Sponsor: Medipol University
Summary
Ribonucleic acids (RNA) are molecules that transfer genetic information from the nucleus to the cytoplasm for protein translation. A subgroup of non-coding or non-messenger RNAs, known as microRNAs (miRNAs), regulates the expression of complementary mRNAs without coding for proteins. In this study, the investigators aimed to evaluate the effect of systemically administered oral isotretinoin on gingival health in terms of microRNA (miRNA), a molecule of interest in periodontal research, before, during, and after treatment.
Official title: Evaluation of the Effect of Systemic Retinoic Acid Use on Micro Ribonucleic Acid (mRNA) Expression in Saliva and Serum
Key Details
Gender
All
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
25
Start Date
2025-09-01
Completion Date
2026-02-01
Last Updated
2025-08-26
Healthy Volunteers
Yes
Conditions
Interventions
Saliva, serum sampling
Saliva were collected to analyze the selected markers as unstimulated samples during the early hours of the day. The saliva was centrifuged and then transferred into Eppendorf tubes. Venous puncture was performed after saliva collection and 10 mL of blood samples were collected by qualified staff from each participant (Periopaper, Oraflow Inc., Plainview, NY, USA). Saliva, serum were then stored at -80 °C until analysis.
oral isotretinoin
oral isotretinoin
Locations (1)
Istanbul Medipol University, School of Dentistry
Istanbul, Fatih, Turkey (Türkiye)