Inclusion Criteria:
* Patients with type 1 diabetes presenting with any of the following conditions:
Impaired hypoglycemia awareness (lack of sufficient autonomic symptoms when plasma glucose is below 54 mg/dL \[3 mmol/L\]) or other clinically diagnosed neuropathy caused by type 1 diabetes, including but not limited to gastrointestinal autonomic neuropathy Metabolic instability: two or more previous severe hypoglycemic events that required assistance from others, or two or more hospitalizations for ketoacidosis in the past year
* Age ≤ 60 years
* Body weight ≥ 40 kg
* At least one positive islet autoantibody, including glutamic acid decarboxylase autoantibody (GADA), protein tyrosine phosphatase autoantibody (IA-2A), insulin autoantibody (IAA) (only applicable within 2 weeks of insulin treatment), zinc transporter 8 antibody (ZnT8), islet cell autoantibody (ICA), etc.
* MMTT stimulated C-peptide peak \> 0.1 nmol/L, or fasting C-peptide \> 0.05 nmol/L
* Female subjects of childbearing potential must have a negative serum or urine pregnancy test at screening
* Both male and female subjects must be willing to use contraception from the time of signing the informed consent form until 12 months after cell infusion
* The subject or their legal guardian voluntarily participates in this study and is able to sign the informed consent form
Exclusion Criteria:
* If any of the following criteria are met, the subject will be excluded from the study.
Type 2 diabetes, or diabetes mellitus from pregnancy, single-gene mutation, pancreatic injury, or other secondary causes (e.g., Cushing's syndrome, thyroid dysfunction, or acromegaly)
* Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ≥ 3 x ULN, or total bilirubin ≥ 1.5 x ULN
* Severe heart disease, with any of the following:
* Myocardial infarction within 1 year before enrollment
* Signs or symptoms of heart failure of NYHA Class ≥ 3 within 1 year before enrollment
* Left ventricular ejection fraction (LVEF) \< 50% at screening
* QTcF \> 450 msec (males) or \> 470 msec (females), based on the QTcF value from a single ECG or the average of three repeated ECGs taken more than 3 minutes apart (QT interval corrected by Fridericia's formula)
* Severe concurrent diabetic nephropathy, with an estimated glomerular filtration rate (eGFR) \< 60 mL/min/1.73 m2
* Currently undergoing or expected to require renal replacement therapy during the study
* At screening, a subject tests positive for hepatitis B surface antigen (HBsAg) and/or hepatitis B e-antigen (HBeAg); a subject tests positive for hepatitis B e-antibody (HBeAb) with a peripheral blood HBV DNA level above the upper limit of normal; a subject tests positive for hepatitis C virus (HCV) antibody; a subject tests positive for human immunodeficiency virus (HIV) antibody; a subject tests positive for syphilis antibody; a subject tests positive for EBER or has an EBV viral load greater than the upper limit of normal
* Participated in another clinical study within 3 months prior to enrollment
* Received a live attenuated vaccine within 4 weeks prior to enrollment
* The investigator considers the patient to have latent T1DM, including latent autoimmune diabetes in adults (LADA) and latent autoimmune diabetes in the young (LADY)
* The investigator believes there are other reasons that make the subject unsuitable for this clinical study
