Clinical Research Directory
Browse clinical research sites, groups, and studies.
Investigating the Impact of Vitamin D Biofortified Tomatoes on Serum Levels of 25(OH)D
Sponsor: Quadram Institute Bioscience
Summary
In the UK, vitamin D deficiency occurs frequently especially during the winter months. Vitamin D biofortified tomatoes have been developed using precision breeding technique by researchers at John Innes Centre. Biofortification uses crop breeding to increase the nutritional value of crops. The goal of the ViTaL-D study is to examine whether the vitamin D biofortified tomatoes when eaten as a soup can increase blood levels of vitamin D in men and women with vitamin D deficiency. Additionally, researchers will learn if the tomato soups are feasible and safe to eat everyday. The main questions the study aims to answer are: * Does vitamin D biofortified tomatoes increase vitamin D levels in men and women with low blood levels of vitamin D? * Is consuming vitamin D biofortified tomatoes safe and easy to eat everyday as a soup? Researchers will compare how four types of tomato soup increase blood vitamin D levels. The four types of soup are: * Soup with vitamin D biofortified tomatoes * Soup with provitamin D biofortified tomatoes * Soup with store-bought tomatoes not containing vitamin D * Soup with store-bought tomatoes with added vitamin D Participants will: * Eat one of the four types of tomato soup every day for 21 days. * Visit the clinic once every 7 days after a 12 hour fast for body measurements, tests, and surveys. * Keep a daily diary when soups are eaten and when time is spent outside.
Official title: Investigating the Impact of Vitamin D Biofortified Tomatoes on Serum Levels of 25(OH)D - a Two Phase, a Randomized Double-blind Placebo-controlled Parallel Arm Trial (RCT)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
76
Start Date
2025-09-01
Completion Date
2028-03-31
Last Updated
2025-08-27
Healthy Volunteers
No
Conditions
Interventions
Precision Bred Provitamin D-rich Tomato Soup
Participants will consume one tomato soup every day for 21 days as part of their normal diet.
Precision Bred Vitamin D-rich Tomato Soup
Participants will consume one tomato soup everyday for 21-days as part of their normal diet.
Wild-type (store-bought) Tomato Soup
Participants will consume one tomato soup every day for 21 days as part of their normal diet.
Wild-type (store-bought) Tomato with vitamin D supplementation Soup
Participants will consume one tomato soup everyday for 21 days as part of their normal diet.
Locations (1)
Quadram Institute Bioscience
Norwich, United Kingdom