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Exercise and/or HMB in Older Diabetes With Low Muscle Mass
Sponsor: Wu Shangling
Summary
The investigators aimed to examine if β-hydroxy-β-methylbutyrate (HMB) supplementation enhances the effects of exercise on muscle mass, physical performance and insulin resistance and observe potential residual effects in older diabetes with low muscle mass, and to find the optimal treatment plan.
Official title: Effects of Exercise and/or β-hydroxy-β-methylbutyrate Supplementation on Muscle Mass, Physical Performance and Insulin Resistance in Older Diabetes With Low Muscle Mass: a Randomized, Double-blind, Placebo-controlled Trial
Key Details
Gender
All
Age Range
60 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2026-04-01
Completion Date
2027-12-31
Last Updated
2026-03-31
Healthy Volunteers
No
Conditions
Interventions
HMB
Participants were instructed to take active products including 3000 mg calcium-HMB per day
Exercise
Participants allocated to the exercise programs were provided 45 min of supervised sessions on 2 nonconsecutive days per week
Placebo
Participants were instructed to take active products including equal in quality resistant dextrin per day
Education
Participants were given health education and educational manuals