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PAXT: Pulmonary Imaging of Mild Asthma Using 129Xe MRI and Tc-99-Labeled-Carbon-Imaging (Tc99CImaging)
Sponsor: Dr. Grace Parraga
Summary
The goal of this observational study is to better understand how asthma affects the lungs in young adults (ages 17-35) with mild asthma. The main questions it aims to answer are: * Can advanced imaging detect abnormal airway function in people with mild asthma? * Do changes in ventilation imaging correlate with asthma symptoms or quality of life? Researchers will compare hyperpolarized xenon-129 MRI and Technegas (Tc-99m) imaging to see if these techniques reveal more detailed lung abnormalities than standard lung function tests. Participants will: * Complete a single 2-hour visit * Undergo two types of lung imaging: Hyperpolarized xenon-129 MRI (to visualize how air moves in the lungs), Technegas (Tc-99m) imaging (to assess airflow using nuclear medicine) * Perform spirometry and other breathing tests * Answer questionnaires about asthma symptoms and quality of life This study is designed to improve our understanding of subtle changes in lung function that may not be detected by standard tests in people with mild asthma. The findings may lead to better diagnostic tools and more personalized treatment strategies in the future.
Key Details
Gender
All
Age Range
17 Years - 35 Years
Study Type
OBSERVATIONAL
Enrollment
40
Start Date
2025-09
Completion Date
2028-12
Last Updated
2025-08-27
Healthy Volunteers
No
Conditions
Interventions
Hyperpolarized 129Xe MRI
Inhalation of hyperpolarized 129Xe gas followed by breath-hold MRI for ventilation imaging.
Tc-99m Technegas Ventilation Imaging
Inhalation of Tc-99m-labeled carbon aerosol (Technegas) followed by SPECT imaging to assess lung ventilation.
Locations (1)
Robarts Research Institute; The University of Western Ontario
London, Ontario, Canada