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Iron Absorption From Plant Heme Iron
Sponsor: ETH Zurich
Summary
Heme, an iron protoporphyin IX complex, consists of a ferrous ion captured in a porphyrin ring acting as a tetradentate ligand. The unique features of heme iron -its unusually high absorption in foods and its resistance to luminal inhibitors of iron absorption- make it a potentially interesting iron fortificant. This study aims to compare fractional iron absorption from two plant-derived heme iron compounds-iron chlorophyllin and soy hemoglobin-with ferrous sulfate (negative control) and porcine hemoglobin (positive control) in iron-deficient women. All four compounds will be intrinsically labeled with stable iron isotopes. Fractional absorption will be assessed 14 days after test meal administration via erythrocyte iron incorporation. Absorption will be tested in two matrices: water and maize porridge (an inhibitory matrix). Each participant will consume all test conditions in a randomized order, allowing for within-subject comparisons.
Official title: Iron Absorption From Plant-Derived Heme Iron: An Experimental Study in Iron-Deficient Women (PHIA)
Key Details
Gender
FEMALE
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
45
Start Date
2025-09-22
Completion Date
2026-05
Last Updated
2026-02-12
Healthy Volunteers
Yes
Conditions
Interventions
Iron chlorophyllin + no-matrix
Water with labelled Fe chlorophyllin (54Fe)
SoyHb + no-matrix
Water with labelled soy hemoglobin (58Fe)
FeSO4 + no-matrix
Water with labelled ferrous sulfate (58Fe)
Hb + no-matrix
Water with labelled porcine hemoglobin (57Fe)
Iron chlorophyllin + meal-matrix
Maize porridge with labelled Fe chlorophyllin (54Fe)
SoyHb + meal-matrix
Maize porridge with labelled soy hemoglobin (58Fe)
FeSO4 + meal-matrix
Maize porridge with labelled ferrous sulfate (57Fe)
Hb + meal-matrix
Maize porridge with labelled porcine hemoglobin (57Fe)
Locations (1)
ETH Zurich, Laboratoy of Clinical Biopharmacy
Zurich, Switzerland