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Prevalence of Liver Dysfunction in Pediatric Patients With Congenital Heart Disease at Assiut.
Sponsor: Assiut University
Summary
Liver dysfunction is a well-documented complication in patients with congenital heart disease (CHD). The mechanisms leading to hepatic dysfunction may be multifactorial. Key risk factors for liver dysfunction in CHD include prolonged hypoxemia, high venous pressure, and prolonged duration of heart disease. While global studies have extensively explored this association, the prevalence of liver dysfunction in CHD varies, with studies reporting hepatic fibrosis in 30-40% of Fontan patients, while regional data, particularly from Egypt, remain limited. In this research we aim to determine the prevalence of biochemical and radiological hepatic abnormalities in pediatric CHD patients attending Assiut University Children's Hospital.
Official title: Prevalence of Liver Dysfunction in Paediatric Patients With Congenital Heart Disease: A Cross-Sectional Study at Assiut University Children Hospital.
Key Details
Gender
All
Age Range
Any - 16 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2025-09-15
Completion Date
2026-03-15
Last Updated
2025-08-27
Healthy Volunteers
No
Interventions
Ultrasonography
Ultrasound, also known as sonography or ultrasonography, is a medical imaging technique that uses high-frequency sound waves to create real-time images of internal body structures
Blood Sampling
To assess hepatic function in congenital heart disease (CHD) patients, blood samples will be collected from all patients in our study for: * Alanine Transferase (ALT). * Aspartate Aminotransferase (AST). * Gamma Glutamyl Transferase (GGT). * Alkaline Phosphatase (ALP). * Total/direct bilirubin. * Albumin. * Prothrombin time. * International Normalized Ratio (INR). * Platelet count.
Locations (1)
Assiut University Children Hospital.
Asyut, Assiut City, Egypt