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Suzetrigine for Acute Pain Control in Patients With Multiple Rib Fractures
Sponsor: University of California, Irvine
Summary
Rib fractures cause a significant amount of pain and are associated with an increased risk of lung infections, long hospitalization, and increased cost. Effective pain control is the cornerstone of management to improve lung function and minimize complications. Most often this is done with a multimodal pain routine consisting of: acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), topical lidocaine, muscle relaxants, and opioids. However, suzetrigine is a promising alternative to treat acute pain associated with rib fractures. We think the addition of suzetrigine to a multimodal pain regimen will improve pain and decrease opioid use.
Official title: Suzetrigine for Acute Pain Control in Patients With Multiple Rib Fractures: A Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2025-11-13
Completion Date
2027-08
Last Updated
2025-12-08
Healthy Volunteers
No
Conditions
Interventions
Suzetrigine (SUZ)
The intervention arm will receive oral suzetrigine (100 mg loading dose followed by 50 mg every 12 hours).
Placebo
The control arm will receive placebo capsules matched to suzetrigine for oral administration.
Locations (1)
University of California, Irvine
Orange, California, United States