Clinical Research Directory

Inclusion Criteria: * Patients of both sex aged 18 years or older * The study will include 60 patients divided into 2 equal groups * Invasive mechanical ventilation * Patients with COPD patients (post-bronchodilator FEV1/FVC\< 70, and under follow through the department outpatient clinic) exacerbation admitted to the ICU and required invasive mechanical ventilation were recruited. Exclusion Criteria: Allergy to sedative which will be used * renal or hepatic impairment * proven or suspected psychiatric or neurological impairment * pregnancy