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Characterization of Primary Central Nervous System Diffuse Large B Cell Lymphoma (PCNS-DLBCL) by Multiomic Approach
Sponsor: International Extranodal Lymphoma Study Group (IELSG)
Summary
PCNS-DLBCL is a rare extranodal non-Hodgkin lymphoma that primarily affects the brain, spine, or vitreoretinal space. The prognosis for PCNS-DLBCL is significantly worse than that for its systemic counterpart. Understanding how and where this tumor initiates, and how it survives or depends on the microenvironment of the CNS is key to understanding the underlying biology and identifying reliable biomarkers for selecting personalized therapy or for biologically directed therapy that could improve the cure rate of CNS lymphomas.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2026-04
Completion Date
2029-12
Last Updated
2025-08-29
Healthy Volunteers
No
Locations (2)
Fondazione IRCCS Policlinico San Matteo Pavia
Pavia, Italy
Oncology Institute of Southern Switzerland and Institute of Oncology Research
Bellinzona, Switzerland