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Inflammatory Biomarkers as Predictors of PONV Following Pediatric Orchiopexy
Sponsor: Diskapi Yildirim Beyazit Education and Research Hospital
Summary
Orchiopexy is a common surgical procedure for the treatment of cryptorchidism in the pediatric population, with a high incidence of postoperative nausea and vomiting (PONV). Recent evidence suggests that systemic inflammation may contribute to PONV pathogenesis, and preoperative inflammatory biomarkers such as NLR, PLR, SII, MLR, and SIRI could serve as predictive indicators. This prospective observational study aims to evaluate the relationship between these biomarkers and PONV incidence in children undergoing orchiopexy.
Official title: Association of Preoperative Inflammatory Biomarkers With Postoperative Nausea and Vomiting in Children Undergoing Orchiopexy
Key Details
Gender
All
Age Range
1 Year - 8 Years
Study Type
OBSERVATIONAL
Enrollment
170
Start Date
2025-09-08
Completion Date
2026-03-27
Last Updated
2025-09-09
Healthy Volunteers
No
Interventions
Measurement of Preoperative Inflammatory Biomarkers
Blood samples will be collected preoperatively to measure inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index, monocyte-to-lymphocyte ratio (MLR), and systemic inflammation response index. These values will be analysed in relation to the incidence of postoperative nausea and vomiting within the first 6 hours after pediatric orchiopexy. No experimental drug or device will be administered as part of the study; all procedures will be conducted within the scope of standard perioperative care.
Locations (1)
Ankara Etlik City Hospital
Altındağ, Ankara, Turkey (Türkiye)