Clinical Research Directory

Inclusion Criteria: Patients in intensive care who gives an informed consent and meet all of the following will be eligible: 1. Admitted to the intensive care unit for \>48 hours. 2. At least 18 years of age 3. Have one or more organ system failure (respiratory,cardiovascular or renal) related to their acute illness defined as: a. PaO2/FiO2≤300 mm Hg) b. Currently on one or more continuous inotrope/vasopressor infusion which were started at least 4 hours ago at a minimum dose of: i. Norepinephrine≥0.1 mcg/kg/min ii. Epinephrine≥0.1 mcg/kg/min iii. Any dose of vasopressin iv. Milrinone\>0.1 mcg/kg/min) c. Renal dysfunction defined as: i. Serum creatinine 2.0-2.9 times baseline or ii. Urine output 0.5 mL/kg/hour for ≥12 hours or iii. Currently receiving renal replacement therapy) d. Currently has an intracranial pressure monitor or ventricular drain in situ 4. Permanent living address in Norway Exclusion Criteria: Patients will be excluded if: 1. Death is imminent in the next 96 hours or there is a current treatment limitation in place or the patient is unlikely to survive to 180 days due to underlying/chronic illness 2. Dialysis dependent chronic renal failure 3. Suspected or known pregnancy 4. Wheelchair user 5. Cognitive impairment in which intervention is considered not appropriate 6. Eating disorders -