Clinical Research Directory

Inclusion Criteria: （1）Age ≥18 years old (2) Clearly diagnosed wAIHA or EVANS syndrome, cAIHA, primary or secondary connective tissue diseases. If it is secondary, there are no indications for the treatment of connective tissue diseases involving other systems. (3) Patients who relapse or are refractory after at least two lines of treatment (previous treatments include glucocorticoids, CD20 monoclonal antibodies or at least two other immunosuppressants). Refractory is defined as the failure to achieve partial remission after 3 months of stable dose treatment with immunosuppressants. (4) hb≤100 g / L (5) Those with complete clinical data, high treatment compliance, and those who have signed the informed consent form; (6) If glucocorticoids are being taken, they should be discontinued or the minimum maintenance dose has been taken for at least two weeks, and the minimum maintenance dose (≤15mg/day) should be continued subsequently (7) The infusion of CD20 monoclonal antibody should be at least 3 months or more. If the stable dose of immunosuppressants such as cyclosporine and sirolimus has been taken for at least 3 months, they should be discontinued upon enrollment. Exclusion Criteria: 1. Those with incomplete functions of organs such as the heart, liver and lungs; Patients with acute renal insufficiency 2. Combined with connective tissue diseases, other vital organs are involved. 3. Uncontrolled infection or bleeding after standard treatment. Standard treatment for uncontrolled active infections of HIV, HCV or HBV. 4. Combined with advanced uncontrolled malignant tumors and lymphomas. 5. At the time of screening, the subjects had other types of uncorrected anemia, such as nutritional anemia, etc 6. Pregnant or lactating women. 7. Those who have used PI3Kδ inhibitors within the past 6 months; 8. Those who have participated in other clinical trials within three months.