Clinical Research Directory

Inclusion Criteria: 1. Diagnosed as HCC through imaging and laboratory tests, and capable of undergoing laparoscopic anatomical resection 2. Those who plan to undergo right or left hemi-liver resection 3. During the operation, the Pringle method was used to block the first hepatic portal. Each block lasted for no more than 15 minutes, and the blocking procedure was performed 2 to 4 times. 4. Age: 18 - 70 years old. Gender: Open to both male and female. Body Mass Index (BMI): 18.5 - 28 kg/m2 5. Child-Pugh grade A or B, with a score of ≤ 7; ASA grades I to III 6. Preoperative ICG R15 was less than 10%, and the residual liver volume was more than 40% of the standard liver volume 7. A single HCC (hepatocellular carcinoma), with a tumor diameter less than 10 cm, without distant metastasis or invasion of the portal vein system 8. Preoperative ALT was less than 2 times the upper limit of normal 9. Before being enrolled in the study, the patient had no history of any other treatments, such as portal vein embolization, TACE or systemic anti-tumor drug therapy. 10. No liver-damaging treatment drugs were used within two weeks prior to enrollment. Exclusion Criteria: 1. Reserve liver vascular damage, including: reconstruction after severance, ligation, embolization, thrombosis, etc 2. Combined with abnormal coagulation function (prothrombin time prolonged by more than 3 seconds) 3. Combining obstructive jaundice, severe heart disease, severe kidney disease and other serious illnesses 4. During the operation, microwave treatment or a combination of microwave treatment was adopted 5. More than 4 times of blocking at the first hepatic hilum, or a single blocking duration longer than 15 minutes 6. Non-anatomic liver resection, where the remaining liver contains large areas of ischemic/edematous regions 7. More than 1000ml of blood transfusion during the operation 8. During the operation, an extra-hepatic disease was discovered. Other organs except the gallbladder needed to be removed simultaneously 9. During the operation, other intrahepatic lesions were discovered, which required combination with other surgeries, such as ablation or choledochojejunostomy 10. Diseases that have previously received systemic treatment with glucocorticoids, such as chronic kidney disease, inflammatory diseases, or other immune system-related disorders 11. Psychosis, severe neurosis, those who cannot cooperate with this experiment 12. Participated in other clinical trials within the previous 3 months before enrollment 13. Allergy or intolerance to benzoic acid, or to the study drug 14. Pregnant and lactating women 15. The researchers believe that any participants who have any other factors that would make them unsuitable for this trial should not be included