Clinical Research Directory

Inclusion Criteria: * Menopausal women (at least 12 months since last menstrual period or bilateral oophorectomy) * Patients with Genitourinary Syndrome and the presence of vulvovaginal atrophy/vestibular trophism alteration (defined as Vaginal Health Index - VHI - less than 15; and Vestibular Trophic Health Score - VeTH - more than 5) and/or initial urinary incontinence based on patient history (stress incontinence , urge incontinence, nicturia reported by patients,) positive IU tests (Stamey score 1: loss of urine with sudden increase in abdominal pressure such as from coughing, sneezing, or laughing) and on a standardized stress test provocation \[(cough test supine and in a standing position with a full bladder (300 ml)\] in healthy post-menopausal women and/or positive OABSS score for overactive bladder. * Patients willing to provide Informed consent to participate in the study. * Women aged between 45 and 65 years. Exclusion Criteria: * Renal insufficiency or sever nephropathy. * In case of known hypersensitivity to one or more of the components contained in the food supplement. * Active or recent (30 days) genitourinary tract infection. * Abnormal uterine bleeding. * Use of lubricants or any other local or systemic preparations, within the 30 days prior to the study. * Genital prolapse (grade II - III according to the Pelvic Organ Prolapse-Quantification, POP-Q, system classification). * Serious or chronic condition that could interfere with study compliance. * Treatment with hormones or other medicines to relieve menopausal symptoms within the 3 months prior the study.