Clinical Research Directory

Inclusion Criteria: * Patients aged ≥ 40 years * meta-polygenic risk score (metaPRS) \> 0.4 * Montreal Cognitive Assessment (MoCA) score ≤ 26 * Central obesity (waist circumference \> 90 cm in males or \> 80 cm in females) or body mass index (BMI) ≥ 28 kg/m² * Written informed consent available * Proficient in using smartphones * Willingness to complete all assessments and participate in follow-up Exclusion Criteria: * Known hypersensitivity or allergy to resistant starch * previously diagnosed dementia * Suspected dementia after clinical assessment by study physician at screening visit * Previous history of major head trauma and any intracranial surgery * Intracranial abnormalities, such as intracerebral hemorrhage, subarachnoid hemorrhage and other space occupying lesions * Extrapyramidal symptoms or mental illness which may affect neuropsychological measurement * Severe loss of vision, hearing, or communicative ability * Patients presenting a malignant disease with life expectancy \< 3 years * Participation in an ongoing investigational drug study * The participant or a first-degree relative is currently participating in another clinical trial involving nutritional intervention. Exit Criteria: * Not meet the inclusion criteria * For any poor adherence, not comply with the requirements of the follow-up, or safety reasons determined by investigator * Any adverse or serious adverse events during the study period judged by Investigator